PLGA Based Nanospheres as a Potent Macrophage-Specific Drug Delivery System
نویسندگان
چکیده
منابع مشابه
[Development of gene delivery system using PLGA nanospheres].
The development of nonviral vectors for the efficient and safe delivery to cells has long been awaited to facilitate gene therapy. Recently, many nonviral vectors modified with cationic lipids, cationic polymers, etc. have been reported. However, those nonviral vectors with cationic materials require improved stability, longer duration of gene expression, and reduced cytotoxicity. We successful...
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PURPOSE Nanoparticles (NPs) that target bone tissue were developed using poly(lactic-co-glycolic acid) (PLGA) copolymers and tetracycline (TC)-based bone-targeting moieties. These NPs are expected to enable the transport of drugs, such as simvastatin (SIM), for the treatment of osteoporosis. METHODS The molecular structures of TC-PLGA were validated by (1)H-NMR, and the SIM-loaded NPs were pr...
متن کاملApplication of a nanoporous metal organic framework based on iron carboxylate as drug delivery system
In the present study, a nanoporous metal organic framework (MOF) based on iron metal and amino terephthalate ligand MIL-101-NH2-Fe has been used as a carrier for loading and in vitro release of 5-flurouracil (5-FU) anticancer drug. The 5-FU drug loaded MOF was 13 wt % by using thermogravimetric analysis (TGA). The 5-FU release was monitored under physiological condition at 37°C, pH 7.4 in simul...
متن کاملApplication of a nanoporous metal organic framework based on iron carboxylate as drug delivery system
In the present study, a nanoporous metal organic framework (MOF) based on iron metal and amino terephthalate ligand MIL-101-NH2-Fe has been used as a carrier for loading and in vitro release of 5-flurouracil (5-FU) anticancer drug. The 5-FU drug loaded MOF was 13 wt % by using thermogravimetric analysis (TGA). The 5-FU release was monitored under physiological condition at 37°C, pH 7.4 in simul...
متن کاملNanospheres : a Novel Approach for Targeted Drug Delivery System
Nanospheres are the particles having the size range between 10-200 nm in diameter. Nanospheres can be amorphous or crystalline in nature and also they have the ability to protect the drug from enzymatic and chemical degradation. It has been shown that the hydrophobic surfaces of these particles are highly susceptible to opsonization and clearance by the reticulo endothelial system. The tiny cap...
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ژورنال
عنوان ژورنال: Nanomaterials
سال: 2021
ISSN: 2079-4991
DOI: 10.3390/nano11030749